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Scientist: Aileen Anderson, Ph.D

Dr. Aileen Anderson

Associate Professor:

Physical Medicine & Rehabilitation
Anatomy & Neurobiology

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Research Focus

Working to understand: spinal cord injury

Scientific Focus: Role of inflammatory mechanisms in degeneration and regeneration in the injured CNS. Human CNS stem cell engraftment in the injured CNS, and mechanisms for the promotion of neurological recovery.

Decorative Icon RECENT PUBLICATIONS ON PUBMED

Selected Publications

Brennan FH, Anderson AJ, Taylor SM, Woodruff TM, Ruitenberg MJ.
Multifunctional, multichannel bridges that deliver neurotrophin encoding lentivirus for Complement activation in the injured central nervous system: another dual-edged sword?
J Neuroinflammation
. 2012 Jun 21;9(1):137. [Epub ahead of print]

Tuinstra HM, Aviles MO, Shin S, Holland SJ, Zelivyanskaya ML, Fast AG, Ko SY, Margul DJ, Bartels AK, Boehler RM, Cummings BJ, Anderson AJ, Shea LD.
Multifunctional, multichannel bridges that deliver neurotrophin encoding lentivirus for regeneration following spinal cord injury. Biomaterials. 2012 Feb;33(5):1618-26. Epub 2011 Nov 29.

Anderson AJ, Haus DL, Hooshmand MJ, Perez H, Sontag CJ, Cummings BJ.
Achieving stable human stem cell engraftment and survival in the CNS: is the future of regenerative medicine immunodeficient? Regen Med. 2011 May;6(3):367-406.

Salazar DL, Uchida N, Hamers FP, Cummings BJ, Anderson AJ.
Human neural stem cells differentiate and promote locomotor recovery in an early chronic spinal cord injury NOD-scid mouse model. PLoS One. 2010 Aug 18;5(8):e12272.

Beck KD, Nguyen HX, Galvan MD, Salazar DL, Woodruff TM, Anderson AJ.
Quantitative analysis of cellular inflammation after traumatic spinal cord injury: evidence for a multiphasic inflammatory response in the acute to chronic environment. Brain. 2010 Feb;133(Pt 2):433-47. Epub 2010 Jan 19.

Luchetti S, Beck KD, Galvan MD, Silva R, Cummings BJ, Anderson AJ.
Comparison of immunopathology and locomotor recovery in C57BL/6, BUB/BnJ, and NOD-SCID mice after contusion spinal cord injury. J Neurotrauma. 2010 Feb;27(2):411-21.

Hooshmand MJ, Sontag CJ, Uchida N, Tamaki S, Anderson AJ, Cummings BJ.
Analysis of host-mediated repair mechanisms after human CNS-stem cell transplantation for spinal cord injury: correlation of engraftment with recovery. PLoS One. 2009. Jun 11;4(6):e5871.

Galvan MD, Luchetti S, Burgos AM, Nguyen HX, Hooshmand MJ, Hamers FP, Anderson AJ.
Deficiency in complement C1q improves histological and functional locomotor outcome after spinal cord injury. J Neurosci. 2008 Dec 17;28(51):13876-88.

Nguyen HX, Galvan MD, Anderson AJ.
Characterization of early and terminal complement proteins associated with polymorphonuclear leukocytes in vitro and in vivo after spinal cord injury. J Neuroinflammation. 2008 Jun 25;5:26.

Nguyen HX, O'Barr TJ, Anderson AJ.
Polymorphonuclear leukocytes promote neurotoxicity through release of matrix metalloproteinases, reactive oxygen species, and TNF-alpha. J Neurochem. 2007 Aug;102(3):900-12. Epub 2007 Jun 11.

Engesser-Cesar C, Ichiyama RM, Nefas AL, Hill MA, Edgerton VR, Cotman CW, Anderson AJ.
Wheel running following spinal cord injury improves locomotor recovery and stimulates serotonergic fiber growth. Eur J Neurosci. 2007 Apr;25(7):1931-9.

Nishi RA, Liu H, Chu Y, Hamamura M, Su MY, Nalcioglu O, Anderson AJ.
Behavioral, histological, and ex vivo magnetic resonance imaging assessment of graded contusion spinal cord injury in mice. Journal of Neurotrauma. 2007 Apr;24(4):674-89.


Contact Information

E-mail:

aja@uci.edu

Phone:

949-824-6750

FAX:

949-824-9728

Address:

Reeve-Irvine Research Center,
1107 Gillespie Neuroscience Building,
University of California,
Irvine, California 92697-4540

The Lab

Hal Nguyen
Project Scientist
Noriko Kamei
Project Scientist
Katja Piltti
Postdoctoral Fellow
Mitra Hooshmand
Postdoctoral Fellow
Hirokazu Saiwai M.D., Ph.D.
Postdoctoral Fellow
Kiran Pawar Ph.D.
Graduate Student
Diane Su
Graduate Student
Francisca Benavente
Graduate Student

Supporting This Work

Donations to labs may be applied in many ways: from costs for experiments to support for a student's stipend.

Join us in becoming a part of scientific history, by supporting the work of this lab.

Learn more by contacting Sara Johnson, sara.johnson@uci.edu, or by visiting our Get Involved Page, where you can donate online.