Scientists: Aileen Anderson, Ph.D.

Research Focus

Working to understand: Spinal cord injury

Scientific Focus: Role of inflammatory mechanisms in degeneration and regeneration in the injured CNS. Human CNS stem cell engraftment in the injured CNS, and mechanisms for the promotion of neurological recovery.

Selected/Recent Publications

Publications Listed on PubMed

Beck KD, Nguyen HX, Galvan MD, Salazar DL, Woodruff TM, Anderson AJ.
Quantitative analysis of cellular inflammation after traumatic spinal cord injury: evidence for a multiphasic inflammatory response in the acute to chronic environment. Brain. 2010 Feb;133(Pt 2):433-47. Epub 2010 Jan 19.

Luchetti S, Beck KD, Galvan MD, Silva R, Cummings BJ, Anderson AJ.
Comparison of immunopathology and locomotor recovery in C57BL/6, BUB/BnJ, and NOD-SCID mice after contusion spinal cord injury. J Neurotrauma. 2010 Feb;27(2):411-21.

Hooshmand MJ, Sontag CJ, Uchida N, Tamaki S, Anderson AJ, Cummings BJ.
Analysis of host-mediated repair mechanisms after human CNS-stem cell transplantation for spinal cord injury: correlation of engraftment with recovery. PLoS One. 2009. Jun 11;4(6):e5871.

Galvan MD, Luchetti S, Burgos AM, Nguyen HX, Hooshmand MJ, Hamers FP, Anderson AJ.
Deficiency in complement C1q improves histological and functional locomotor outcome after spinal cord injury. J Neurosci. 2008 Dec 17;28(51):13876-88.

Laporte LD, Yang Y, Zelivyanskaya ML, Cummings BJ, Anderson AJ, Shea LD.
Plasmid Releasing Multiple Channel Bridges for Transgene Expression After Spinal Cord Injury. Mol Ther. 2008 Dec 2. [Epub ahead of print]

Nguyen HX, Galvan MD, Anderson AJ.
Characterization of early and terminal complement proteins associated with polymorphonuclear leukocytes in vitro and in vivo after spinal cord injury. J Neuroinflammation. 2008 Jun 25;5:26.

Nguyen HX, O'Barr TJ, Anderson AJ.
Polymorphonuclear leukocytes promote neurotoxicity through release of matrix metalloproteinases, reactive oxygen species, and TNF-alpha. J Neurochem. 2007 Aug;102(3):900-12. Epub 2007 Jun 11.

Engesser-Cesar C, Ichiyama RM, Nefas AL, Hill MA, Edgerton VR, Cotman CW, Anderson AJ.
Wheel running following spinal cord injury improves locomotor recovery and stimulates serotonergic fiber growth. Eur J Neurosci. 2007 Apr;25(7):1931-9.

Nishi RA, Liu H, Chu Y, Hamamura M, Su MY, Nalcioglu O, Anderson AJ.
Behavioral, histological, and ex vivo magnetic resonance imaging assessment of graded contusion spinal cord injury in mice. Journal of Neurotrauma. 2007 Apr;24(4):674-89.

Cummings BJ, Engesser-Cesar C, Cadena G, Anderson AJ.
Adaptation of a ladder beam walking task to assess locomotor recovery in mice following spinal cord injury. Behav Brain Res. 2007 Feb 27;177(2):232-41. Epub 2007 Jan 2.

Cummings BJ, Uchida N, Tamaki SJ, Anderson AJ.
Human neural stem cell differentiation following transplantation into spinal cord injured mice: association with recovery of locomotor function. Neurol Res. 2006 Jul;28(5):474-81.

Basso DM, Fisher LC, Anderson AJ, Jakeman LB, McTigue DM, Popovich PG.
Basso Mouse Scale for locomotion detects differences in recovery after spinal cord injury in five common mouse strains. J Neurotrauma. 2006 May;23(5):635-59.