Working to understand: Spinal cord injury
Scientific Focus: Role of inflammatory mechanisms in degeneration and regeneration in the injured CNS. Human CNS stem cell engraftment in the injured CNS, and mechanisms for the promotion of neurological recovery.
Multifunctional, multichannel bridges that deliver neurotrophin encoding lentivirus for Complement activation in the injured central nervous system: another dual-edged sword?
J Neuroinflammation. 2012 Jun 21;9(1):137. [Epub ahead of print]
Tuinstra HM, Aviles MO, Shin S, Holland SJ, Zelivyanskaya ML, Fast AG, Ko SY,
Margul DJ, Bartels AK, Boehler RM, Cummings BJ,
Multifunctional, multichannel bridges that deliver neurotrophin encoding lentivirus for regeneration following spinal cord injury. Biomaterials. 2012 Feb;33(5):1618-26. Epub 2011 Nov 29.
Achieving stable human stem cell engraftment and survival in the CNS: is the future of regenerative medicine immunodeficient? Regen Med. 2011 May;6(3):367-406.
Salazar DL, Uchida N, Hamers FP, Cummings BJ,
Human neural stem cells differentiate and promote locomotor recovery in an early chronic spinal cord injury NOD-scid mouse model. PLoS One. 2010 Aug 18;5(8):e12272.
Beck KD, Nguyen HX, Galvan MD, Salazar DL, Woodruff TM,
Quantitative analysis of cellular inflammation after traumatic spinal cord injury: evidence for a multiphasic inflammatory response in the acute to chronic environment. Brain. 2010 Feb;133(Pt 2):433-47. Epub 2010 Jan 19.
Luchetti S, Beck KD, Galvan MD, Silva R, Cummings BJ,
Comparison of immunopathology and locomotor recovery in C57BL/6, BUB/BnJ, and NOD-SCID mice after contusion spinal cord injury. J Neurotrauma. 2010 Feb;27(2):411-21.
Hooshmand MJ, Sontag CJ, Uchida N, Tamaki S,
Analysis of host-mediated repair mechanisms after human CNS-stem cell transplantation for spinal cord injury: correlation of engraftment with recovery. PLoS One. 2009. Jun 11;4(6):e5871.
Galvan MD, Luchetti S, Burgos AM, Nguyen HX, Hooshmand MJ, Hamers FP,
Deficiency in complement C1q improves histological and functional locomotor outcome after spinal cord injury. J Neurosci. 2008 Dec 17;28(51):13876-88.
Nguyen HX, Galvan MD,
Characterization of early and terminal complement proteins associated with polymorphonuclear leukocytes in vitro and in vivo after spinal cord injury. J Neuroinflammation. 2008 Jun 25;5:26.
Nguyen HX, O'Barr TJ,
Polymorphonuclear leukocytes promote neurotoxicity through release of matrix metalloproteinases, reactive oxygen species, and TNF-alpha. J Neurochem. 2007 Aug;102(3):900-12. Epub 2007 Jun 11.
Engesser-Cesar C, Ichiyama RM, Nefas AL, Hill MA, Edgerton VR, Cotman CW,
Wheel running following spinal cord injury improves locomotor recovery and stimulates serotonergic fiber growth. Eur J Neurosci. 2007 Apr;25(7):1931-9.
Nishi RA, Liu H, Chu Y, Hamamura M, Su MY, Nalcioglu O,
Behavioral, histological, and ex vivo magnetic resonance imaging assessment of graded contusion spinal cord injury in mice. Journal of Neurotrauma. 2007 Apr;24(4):674-89.
Reeve-Irvine Research Center,
1107 Gillespie Neuroscience Building,
University of California,
Irvine, California 92697-4540
Hirokazu Saiwai M.D., Ph.D.
Kiran Pawar Ph.D.
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