Anatomy & Neurobiology
Working to understand: (1) How the brain becomes epileptic (2) how early-life stress, enriched-experience or seizures result in enduring changes of hippocampal structure and function (learning and memory) (3) Mechanisms of resilience to stress-related disorders.
Scientific Focus: (a) Enduring neuroplasticity,via epigenetic programming and altered connectivity, of hippocampal and hypothalamic neurons that is induced by early life enriched-experience, stress or seizures. b) Febrile seizures and epilepsy: contributions of ion channel expression and trafficking, biomarkers of epileptogenesis, inflammation.
Chen Y, Kramár EA, Chen LY, Babayan AH, Andres AL, Gall CM, Lynch G,
Impairment of synaptic plasticity by the stress mediator CRH involves selective destruction of thin dendritic spines via RhoA signaling. Mol Psychiatry, 2013.
The brain, seizures and epilepsy throughout life: understanding a moving target. Epilepsy Curr. 2012 Jul;12(Suppl 3):7-12.
Sculpting the Hippocampus from within: Stress, Spines, and CRH. Trends Neurosci, 35:315-24, 2012.
Vezzani A, French J, Bartfai T,
The role of inflammation in epilepsy. Nat Rev Neurol, 7:31-40, 2011.
McClelland S, Flynn C, Dubé C, Richichi C, Zha QQ, Ghestem A, Esclapez M, Bernard C,
Neuron-restrictive silencer factor-mediated hyperpolarization activated, cyclic nucleotide gated channelopathy in experimental temporal lobe epilepsy. Ann Neurol, 70:454-65, 2011.
Noam Y, Bernard C,
Towards an integrated view of HCN channel role in epilepsy. Curr Opin Neurobiol, 21:873-79, 2011.
Ivy A, Rex C, Chen Y, Dubé C, Maras P, Grigoriadis D, Gall C, Lynch G,
Hippocampal dysfunction and cognitive impairments provoked by chronic early-life stress involve activation of CRH receptors. J Neurosci 30:13005-15, 2010.
Dubé CM, Ravizza T, Hamamura M, Zha Q, Keebaugh A, Fok K, Andres AL, Nalcioglu O, Obenaus A, Vezzani A,
Epileptogenesis provoked by prolonged experimental febrile seizures: mechanisms and biomarkers. J Neurosci, 30:7484-94, 2010.
Korosi A, Shanabrough M, McClelland S, Liu ZW, Borok E, Gao XB, Horvath TL,
Early-life experience reduces excitation to stress-responsive hypothalamic neurons and re-programs the expression of corticotropin releasing hormone. J Neurosci, 30:703-13, 2010.
The Neuro-symphony of Stress. Nature Reviews Neuroscience, 10:459-66, 2009.
B151, C237 Med Sci I,
University of California
Irvine, California 92697-4475
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