Emeritus Faculty

  • Robert Blanks
  • Ralph Bradshaw
  • Earl Davis
  • James Fallon
  • Roland Giolli
  • Leonard Kitzes
  • Charles Ribak
  • John Swett
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Scientists: Tallie Z. Baram, M.D., Ph.D.

Dr. Tallie Z. Baram and Lab

Professor:

Pediatrics
Anatomy & Neurobiology
Neurology

Decorative Icon Baram Home Page     Decorative Icon Biography     Decorative Icon Research
Decorative Icon Epilepsy Research Center

Research Focus

Working to understand: (1) How the brain becomes epileptic (2) how early-life stress, enriched-experience or seizures result in enduring changes of hippocampal structure and function (learning and memory) (3) Mechanisms of resilience to stress-related disorders.

Scientific Focus: (a) Enduring neuroplasticity,via epigenetic programming and altered connectivity, of hippocampal and hypothalamic neurons that is induced by early life enriched-experience, stress or seizures. b) Febrile seizures and epilepsy: contributions of ion channel expression and trafficking, biomarkers of epileptogenesis, inflammation.

Decorative Icon RECENT PUBLICATIONS ON PUBMED

Selected Publications

Chen Y, Kramár EA, Chen LY, Babayan AH, Andres AL, Gall CM, Lynch G, Baram TZ.
Impairment of synaptic plasticity by the stress mediator CRH involves selective destruction of thin dendritic spines via RhoA signaling. Mol Psychiatry, 2013.

Baram TZ.
The brain, seizures and epilepsy throughout life: understanding a moving target. Epilepsy Curr. 2012 Jul;12(Suppl 3):7-12.

Maras PM, Baram TZ.
Sculpting the Hippocampus from within: Stress, Spines, and CRH. Trends Neurosci, 35:315-24, 2012.

Vezzani A, French J, Bartfai T, Baram TZ.
The role of inflammation in epilepsy. Nat Rev Neurol, 7:31-40, 2011.

McClelland S, Flynn C, Dubé C, Richichi C, Zha QQ, Ghestem A, Esclapez M, Bernard C, Baram TZ.
Neuron-restrictive silencer factor-mediated hyperpolarization activated, cyclic nucleotide gated channelopathy in experimental temporal lobe epilepsy. Ann Neurol, 70:454-65, 2011.

Noam Y, Bernard C, Baram TZ.
Towards an integrated view of HCN channel role in epilepsy. Curr Opin Neurobiol, 21:873-79, 2011.

Ivy A, Rex C, Chen Y, Dubé C, Maras P, Grigoriadis D, Gall C, Lynch G, Baram TZ.
Hippocampal dysfunction and cognitive impairments provoked by chronic early-life stress involve activation of CRH receptors. J Neurosci 30:13005-15, 2010.

Dubé CM, Ravizza T, Hamamura M, Zha Q, Keebaugh A, Fok K, Andres AL, Nalcioglu O, Obenaus A, Vezzani A, Baram TZ.
Epileptogenesis provoked by prolonged experimental febrile seizures: mechanisms and biomarkers. J Neurosci, 30:7484-94, 2010.

Korosi A, Shanabrough M, McClelland S, Liu ZW, Borok E, Gao XB, Horvath TL, Baram TZ.
Early-life experience reduces excitation to stress-responsive hypothalamic neurons and re-programs the expression of corticotropin releasing hormone. J Neurosci, 30:703-13, 2010.

Joëls M, Baram TZ.
The Neuro-symphony of Stress. Nature Reviews Neuroscience, 10:459-66, 2009.

Contact Information

E-mail:

tallie@uci.edu

FAX:

949-824-1106

Address:

B151, C237 Med Sci I,
University of California
Irvine, California 92697-4475

The Lab

Celine Dube, Ph.D.
Assoc. Project Scientist
Yuncai Chen, Ph.D.
Assoc. Project Scientist
Akanksha Singh, Ph.D.
Postdoctoral Fellow
Mankin Choy, Ph.D.
Postdoctoral Researcher
Limor Regev, Ph.D.
Postdoctoral Researcher
Yoav Noam, Ph.D.
Postdoctoral Researcher
Jenny Molet, Ph.D.
Postdoctoral Researcher
Gary Brennan, Ph.D.
Postdoctoral Researcher
Adrienne Andres, B.Sc.
Postdoctoral Researcher
Kate Patterson, B.A.
Graduate Student
Annie Koh, B.Sc.
Lab Manager
Heather Boyle, B.Sc.
Co-Lab Manager

Supporting This Work

Donations to labs may be applied in many ways: from costs for experiments to support for a student's stipend.

Join us in becoming a part of scientific history, by supporting the work of this lab.

Learn more by contacting Sara Johnson, sara.johnson@uci.edu, or by visiting our Get Involved Page, where you can donate online.