Scientists: Anne Calof, Ph.D.

Research Focus

Working to understand: Molecular etiology of human developmental disorders, feedback interactions regulating neurogenesis, roles of TGF-betas and FGFs in development

Scientific Focus: Molecular biology of neural development and regeneration.

Recent Publications

The Latest via PubMed

Beites, CL, Hollenbeck, PLW, Kim, J, Lovell-Badge, R, Lander, AD, and Calof, AL (2009) Follistatin modulates a BMP autoregulatory loop to control size and patterning of sensory domains in the developing tongue. In press, Development.

Gokoffski, K.K., Kawauchi, S., H.-H. Wu, R. Santos, P.W.L. Hollenbeck, A.D. Lander and A.L. Calof (2009) "Feedback regulation of neurogenesis in the mammalian olfactory epithelium: New insights from genetics and systems biology." In: Neurobiology of Olfaction, A. Menini, Ed. CRC Press, In press.

Kawauchi, S, Santos, R, KIm, J, Hollenbeck, PLW, Murray, RC, and Calof, AL (2009) The role of Foxg1 in the development of neural stem cells of the olfactory epithelium. Ann. NY Acad. Sci., In press.

Kawauchi, S., Kim, J., Santos, R., Wu, H. H., Lander, A. D. and Calof, A. L. (2009). Foxg1 promotes olfactory neurogenesis by antagonizing Gdf11. Development 136, 1453-64.

Lander, A.D., Gokoffski, K.K., Wan, F., Nie, Q., and Calof, A.L. (2009) Cell Lineages and the logic of proliferative control. PLoS Biology 7(1) : e1000015. doi:10.1371/journal.pbio.1000015.

Lo, W-C, Chou, C-S, Gokoffski, KK, Wan, FYM, Lander, AD, Calof, AL, and Nie, Q (2009) Feedback regulation in multistage cell lineages. Mathematical Biosciences and Engineering,6(1): 59-82.

Hamilton, JA, Beites, CL, Gokoffski, KK, Hollenbeck PLW, Kawauchi, S, Santos R, Bonnin A, Wu HH, Kim J, & Calof, A.L. (2008) Negative regulation of endogenous stem cells in sensory neuroepithelia: implications for neurotherapeutics. Stem Cell Research and Therapeutics, Y. Shi, D. Clegg (Eds.) Springer, pp. 45-68

Kawauchi S., Shou, J., Santos R., Hebert J., McConnell S.K., Mason, I., and Calof, A.L. (2005) Fgf8 expression defines a morphogenetic center required for olfactory neurogenesis and nasal cavity development in the mouse. Development, 132: 5211-5223.

Kim, J., Wu, H.-H., Lander, A.D., Lyons, K.M., Matzuk, M. M., and Calof, A.L. (2005). GDF11 controls the timing of progenitor cell competence in developing retina. Science 308: 1927-1930.

Kawauchi, S., Beites, C., Crocker, C., Wu, H.-H., Bonnin, A., Murray, R., and Calof, A.L. (2004). Molecular regulation of neurogenesis in the olfactory receptor neuron lineage. Devel. Neuroscience 26: 166-180.

Krantz ID, McCallum J, DeScipio C, Kaur M, Gillis L, Yaeger D, Jukofsky L, Wasserman N, Bottani A, Morris CA, Nowaczyk N, Toriello H, Bamshad MJ, Carey JC, Rappaport E, Kawauchi S, Lander AD, Calof AL, Ki H-H, Devoto M, and Jackson LG (2004) Cornelia de Lange Syndrome is caused by mutations in NIPBL, the human homolog of the DrosophilaNipped-B gene. Nature Genetics 36: 631-635.

Murray, RC, Navi D, Fesenko J, Lander A., and Calof AL (2003). Widespread defects in the primary olfactory pathway caused by loss of Mash1 function. Journal of Neuroscience 23: 1769-1780.

Wu H H, Ivkovic S, Murray RC, Jaramillo S., Lyons KM, Johnson JE., and Calof, AL (2003). Autoregulation of neurogenesis by GDF11. Neuron 37: 197-207.