Scientists: Anne Calof, Ph.D.

Research Focus

Working to understand: Molecular etiology of human developmental disorders, feedback interactions regulating neurogenesis, roles of TGF-betas and FGFs in development

Scientific Focus: Molecular biology of neural development and regeneration.

Selected/Recent Publications

Publications Listed on PubMed

Chien R, Zeng W, Kawauchi S, Bender MA, Santos R, Gregson HC, Schmiesing JA, Newkirk DA, Kong X, Ball AR Jr, Calof AL, Lander AD, Groudine MT, Yokomori K.
Cohesin Mediates Chromatin Interactions That Regulate Mammalian {beta}-globin Expression. J Biol Chem. 2011 May 20;286(20):17870-8. Epub 2011 Mar 29.

Chou CS, Lo WC, Gokoffski KK, Zhang YT, Wan FY, Lander AD, Calof AL, Nie Q.
Spatial dynamics of multistage cell lineages in tissue stratification. Biophys J. 2010 Nov 17;99(10):3145-54.

Chien R, Zeng W, Kawauchi S, Bender MA, Santos R, Gregson HC, Schmiesing JA, Newkirk DA, Kong X, Ball AR Jr, Calof AL,Lander AD, Groudine MT, Yokomori K.
Cohesin Mediates Chromatin Interactions That Regulate Mammalian {beta}-globin Expression. J Biol Chem. 2011 May 20;286(20):17870-8. Epub 2011 Mar 29.

Chou CS, Lo WC, Gokoffski KK, Zhang YT, Wan FY, Lander AD, Calof AL, Nie Q.
Spatial dynamics of multistage cell lineages in tissue stratification. Biophys J. 2010 Nov 17;99(10):3145-54.

Kawauchi S, Calof AL, Santos R, Lopez-Burks ME, Young CM, Hoang MP, Chua A, Lao T, Lechner MS, Daniel JA, Nussenzweig A, Kitzes L, Yokomori K, Hallgrimsson B, Lander AD.
Multiple organ system defects and transcriptional dysregulation in the Nipbl(+/-) mouse, a model of Cornelia de Lange Syndrome. PLoS Genet. 2009 Sep;5(9):e1000650. Epub 2009 Sep 18.

Kawauchi, S*, Calof, AL*, Santos, R., Lopez-Burks, ME, Young, CM, Hoang, MP, Chua, A., Lao, T., Lechner, MS, Daniel, JA, Nussenzweig, A., Kitzes, L., Yokomori, K., Hallgrimsson, B. and Lander, A.D. (2009) Multiple organ system defects and transcriptional dysregulation in a mouse model of Cornelia de Lange Syndrome. PLoS Genetics Sep;5(9):e1000650. Epub 2009 Sep 18. (* = Co-first authors)

Beites, CL, Hollenbeck, PLW, Kim, J, Lovell-Badge, R, Lander, AD, and Calof, AL (2009) Follistatin modulates a BMP autoregulatory loop to control size and patterning of sensory domains in the developing tongue. Development, 136: 2187-2197

Gokoffski, K.K., Kawauchi, S., H.-H. Wu, R. Santos, P.W.L. Hollenbeck, A.D. Lander and A.L. Calof (2009) Feedback regulation of neurogenesis in the mammalian olfactory epithelium: New insights from genetics and systems biology. Neurobiology of Olfaction, (A. Menini, Ed.), CRC Press, pp. 241-265.

Kawauchi, S, Santos, R, KIm, J, Hollenbeck, PLW, Murray, RC, and Calof, AL (2009) The role of Foxg1 in the development of neural stem cells of the olfactory epithelium. Ann. NY Acad. Sci., 2009 Jul;1170:21-7.

Kawauchi, S., Kim, J., Santos, R., Wu, H. H., Lander, A. D. and Calof, A. L. (2009). Foxg1 promotes olfactory neurogenesis by antagonizing Gdf11. Development 136, 1453-64.

Lander, A.D., Gokoffski, K.K., Wan, F., Nie, Q., and Calof, A.L. (2009) Cell Lineages and the logic of proliferative control. PLoS Biology PLoS Biol. 2009 Jan 20;7(1):e15.

Lo, W-C, Chou, C-S, Gokoffski, KK, Wan, FYM, Lander, AD, Calof, AL, and Nie, Q (2009) Feedback regulation in multistage cell lineages. Mathematical Biosciences and Engineering,6(1): 59-82.