Emeritus Faculty

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Scientist: Brian J. Cummings, Ph.D.

Dr. Brian Cummings


Physical Medicine & Rehabilitation,
Anatomy & Neurobiology

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Research Focus

Working to understand: How neural stem cells interpret the niche; how transplanted stem cells integrate with the host; how best to use neural stem cells to treat CNS injuries, integration of biomaterials with the CNS.

Scientific Focus: Derivation and characterization of ES, iPS, and adult neural stem cell lines. Interaction between human neural stem cells and the injured CNS. Therapeutic use of human neural stem cells using in vitro models (real-time imaging, organotypic cultures) and in vivo models of disease (spinal cord injury, traumatic brain injury, neurodegenerative diseases).


Selected Publications

Functional assessment of long-term deficits in rodent models of traumatic brain injury.
Gold EM, Su D, López-Velázquez L, Haus DL, Perez H, Lacuesta GA, Anderson AJ, Cummings BJ.
Regen Med. 2013 Jul;8(4):483-516. doi: 10.2217/rme.13.41.

Immunosuppressants Affect Human Neural Stem Cells In Vitro but Not in an In Vivo Model of Spinal Cord Injury.
Sontag CJ, Nguyen HX, Kamei N, Uchida N, Anderson AJ, Cummings BJ.
Stem Cells Transl Med. 2013 Aug 27.

Human neural stem cells induce functional myelination in mice with severe dysmyelination.
Uchida N, Chen K, Dohse M, Hansen KD, Dean J, Buser JR, Riddle A, Beardsley DJ, Wan Y, Gong X, Nguyen T, Cummings BJ, Anderson AJ, Tamaki SJ, Tsukamoto A, Weissman IL, Matsumoto SG, Sherman LS, Kroenke CD, Back SA.
Sci Transl Med. 2012 Oct 10;4(155):155ra136.

Multifunctional, multichannel bridges that deliver neurotrophin encoding lentivirus for regeneration following spinal cord injury.
Tuinstra HM, Aviles MO, Shin S, Holland SJ, Zelivyanskaya ML, Fast AG, Ko SY, Margul DJ, Bartels AK, Boehler RM, Cummings BJ, Anderson AJ, Shea LD.

Biomaterials. 2012 Feb;33(5):1618-26. Epub 2011 Nov 29.

Achieving stable human stem cell engraftment and survival in the CNS: is the future of regenerative medicine immunodeficient?
Anderson AJ, Haus DL, Hooshmand MJ, Perez H, Sontag CJ, Cummings BJ.
Regen Med. 2011 May;6(3):367-406.

Adaptation of a ladder beam walking task to assess locomotor recovery in mice following spinal cord injury.
Cummings BJ, Engesser-Cesar C, Cadena G, Anderson AJ.
Behav Brain Res. 2007 Feb 27;177(2):232-41. Epub 2007 Jan 2.

Human neural stem cells differentiate and promote locomotor recovery in spinal cord-injured mice.
Cummings BJ, Uchida N, Tamaki SJ, Salazar DL, Hooshmand M, Summers R, Gage FH, Anderson AJ.
Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):14069-74. Epub 2005 Sep 19.

Contact Information








845 Health Sciences Road,
Gross Hall, Rm 2026,
UCI School of Medicine,
Irvine, CA 92697-1705

The Lab

Katja Piltti
Postdoctoral Fellow
Luci López-Velázquez
Postdoctoral Fellow
Daniel Haus
Graduate Student
Eric Gold
Graduate Student
Harvey Perez
Kelly Cunningham

Supporting This Work

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Join us in becoming a part of scientific history, by supporting the work of this lab.

Learn more by contacting Pamela Foster, pamela.foster@uci.edu, or by visiting our Get Involved Page, where you can donate online.