Working to understand: How neural stem cells interpret the niche; how transplanted stem cells integrate with the host; how best to use neural stem cells to treat CNS injuries, integration of biomaterials with the CNS.
Scientific Focus: Derivation and characterization of ES, iPS, and adult neural stem cell lines. Interaction between human neural stem cells and the injured CNS. Therapeutic use of human neural stem cells using in vitro models (real-time imaging, organotypic cultures) and in vivo models of disease (spinal cord injury, traumatic brain injury, neurodegenerative diseases).
Functional assessment of long-term deficits in rodent models of traumatic brain injury.
Gold EM, Su D, López-Velázquez L, Haus DL, Perez H, Lacuesta GA, Anderson AJ,
Regen Med. 2013 Jul;8(4):483-516. doi: 10.2217/rme.13.41.
Immunosuppressants Affect Human Neural Stem Cells In Vitro but Not in an In Vivo Model of Spinal Cord Injury.
Sontag CJ, Nguyen HX, Kamei N, Uchida N, Anderson AJ, .
Stem Cells Transl Med. 2013 Aug 27.
Human neural stem cells induce functional myelination in mice with severe dysmyelination.
Uchida N, Chen K, Dohse M, Hansen KD, Dean J, Buser JR, Riddle A, Beardsley DJ, Wan Y, Gong X, Nguyen T,, Anderson AJ, Tamaki SJ, Tsukamoto A, Weissman IL, Matsumoto SG, Sherman LS, Kroenke CD, Back SA.
Sci Transl Med. 2012 Oct 10;4(155):155ra136.
Multifunctional, multichannel bridges that deliver neurotrophin encoding lentivirus for regeneration following spinal cord injury.
Tuinstra HM, Aviles MO, Shin S, Holland SJ, Zelivyanskaya ML, Fast AG, Ko SY, Margul DJ, Bartels AK, Boehler RM, Anderson AJ, Shea LD.
Biomaterials. 2012 Feb;33(5):1618-26. Epub 2011 Nov 29.
Achieving stable human stem cell engraftment and survival in the CNS: is the future of regenerative medicine immunodeficient?
Anderson AJ, Haus DL, Hooshmand MJ, Perez H, Sontag CJ,
Regen Med. 2011 May;6(3):367-406.
Adaptation of a ladder beam walking task to assess locomotor recovery in mice following spinal cord injury.
Engesser-Cesar C, Cadena G, Anderson AJ.
Behav Brain Res. 2007 Feb 27;177(2):232-41. Epub 2007 Jan 2.
Human neural stem cells differentiate and promote locomotor recovery in spinal cord-injured mice.
, Uchida N, Tamaki SJ, Salazar DL, Hooshmand M, Summers R, Gage FH, Anderson AJ.
Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):14069-74. Epub 2005 Sep 19.
845 Health Sciences Road, Gross Hall, Rm 2026,
UCI School of Medicine,
Irvine, CA 92697-1705
CSULB CIRM Intern
CSUF CIRM Intern
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