Anatomy & Neurobiology
Neurobiology & Behavior
Working to understand: cellular mechanisms of synaptic plasticity, learning
Scientific Focus: regulation of neuronal gene expression, neurotrophic factors and adhesion molecules in neuroplasticity and neuronal survival.
Lauterborn JC, Jafari M, Babayan AH &
(2015). Environmental enrichment reveals effects of genotype on hippocampal spine morphologies in the mouse model of Fragile X Syndrome. Cereb Cortex 25, 516-527.
Trieu B.H., E.A. Kramar, W. Wang, C.D. Cox,
2015 Differences in adenosine processing create marked regional variations in post-induction shaping of memory related synaptic changes. J. Physiology, 593 (13): 2889-2907. doi: 10.1113/JP270398
Seese, R.R., Maske A.R., Lynch G. and
2014 Long-term memory deficits are associated with elevated synaptic ERK1/2 activation and reversed by mGluR5 antagonism in an animal model of autism. Neuropsychopharmacology, 39: 1664-1674. doi: 10.1038/npp.2014.13.
Cox, C.D., C.S. Rex, L.C. Palmer, A.H. Babayan, D.T. Pham, S.D. Corwin, B.H. Trieu,
2014 A map of LTP-related synaptic changes in dorsal hippocampus following unsupervised leaning. J. Neurosci 34: 3033-3041.
Seese, R.R., Y.Q. Yao, K. Wang, G. Lynch and
2014 Spaced training rescues memory and synaptic ERK1/2 signaling in a mouse model of fragile X syndrome. Proc Natl Acad Sci, USA. Nov 25;111(47):16907-12. doi: 10.1073/pnas.1413335111. Epub 2014 Nov 10.
Lynch G, Kramár EA, Babayan AH, Rumbaugh G,
Differences between synaptic plasticity thresholds result in new timing rules for maximizing long-term potentiation. Neuropharmacology. 2013 Jan;64:27-36.
Jafari M, Seese RR, Babayan AH,
Glucocorticoid receptors are localized to dendritic spines and influence local actin signaling. Mol Neurobiol. 2012 Oct;46(2):304-15.
Babayan AH, Kramár EA, Barrett RM, Jafari M, Häettig J, Chen LY, Rex CS, Lauterborn JC, Wood MA,
Integrin dynamics produce a delayed stage of long-term potentiation and memory consolidation. J Neurosci. 2012 Sep 12;32(37):12854-61.
Seese RR, Babayan AH, Katz AM, Cox CD, Lauterborn JC, Lynch G,
LTP induction translocates cortactin at distant synapses in wild-type but not FMR1 knock-out mice. J Neurosci. 2012 May 23;32(21):7403-13.
Kramár EA, Babayan AH, Gavin CF, Cox CD, Jafari M, Gall CM, Rumbaugh G,
Synaptic evidence for the efficacy of spaced learning. Proc Natl Acad Sci U S A. 2012 Mar 27;109(13):5121-6. Epub 2012 Mar 12.
Chen LY, Rex CS, Pham DT, Lynch G, Gall CM. BDNF signaling during learning is regionally differentiated within hippocampus. J Neurosci. 2010 Nov 10;30(45):15097-101.
Chen, LY, CS Rex, A.H. Babayan, E.A. Kramar, G. Lynch, Journal of Neuroscience. 2010 Aug 18;30(33):10977-84.and J.C. Lauterborn. Physiological activation of synaptic Rac > PAK signaling is defective in a mouse model of Fragile-X Syndrome. In press,
Chen LY, Rex CS, Sanaiha Y, Lynch G, Proc Natl Acad Sci U S A. 2010 Apr 13;107(15):7030-5. Epub 2010 Mar 30.Learning induces neurotrophin signaling at hippocampal synapses.
Dep't Anatomy & Neurobiology,
School of Medicine,
Gillespie Neuroscience Research Facility,
University of California,
Irvine, CA 92797-1275
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