Scientists: Christine M. Gall, Ph.D.

Research Focus

Working to understand: cellular mechanisms of synaptic plasticity, learning

Scientific Focus: regulation of neuronal gene expression, neurotrophic factors and adhesion molecules in neuroplasticity and neuronal survival.

Selected/Recent Publications

Publications Listed on PubMed

Lynch G, Palmer LC, Gall CM.
The likelihood of cognitive enhancement. Pharmacol Biochem Behav. 2011 Jan 6. [Epub ahead of print]

Chen LY, Rex CS, Pham DT, Lynch G, Gall CM. BDNF signaling during learning is regionally differentiated within hippocampus. J Neurosci. 2010 Nov 10;30(45):15097-101.

Simmons DA, Mehta RA, Lauterborn JC, Gall CM, Lynch G.
Brief ampakine treatments slow the progression of Huntington's disease phenotypes in R6/2 mice. Neurobiol Dis. 2011 Feb;41(2):436-44. Epub 2010 Oct 23.

Chen, LY, CS Rex, A.H. Babayan, E.A. Kramar, G. Lynch, C.M. Gall and J.C. Lauterborn. Physiological activation of synaptic Rac > PAK signaling is defective in a mouse model of Fragile-X Syndrome. In press, Journal of Neuroscience. 2010 Aug 18;30(33):10977-84.

Chen LY, Rex CS, Sanaiha Y, Lynch G, Gall CM. Learning induces neurotrophin signaling at hippocampal synapses. Proc Natl Acad Sci U S A. 2010 Apr 13;107(15):7030-5. Epub 2010 Mar 30.

Kramár EA, Chen LY, Brandon NJ, Rex CS, Liu F, Gall CM, Lynch G. Cytoskeletal changes underlie estrogen's acute effects on synaptic transmission and plasticity. J Neurosci. 2009 Oct 14;29(41):12982-93.

Rex CS, Chen LY, Sharma A, Liu J, Babayan AH, Gall CM, Lynch G. Different Rho GTPase-dependent signaling pathways initiate sequential steps in the consolidation of long-term potentiation. J Cell Biol. 2009 Jul 13;186(1):85-97.

Lauterborn JC, Pineda E, Chen LY, Ramirez EA, Lynch G, Gall CM.
Ampakines cause sustained increases in brain-derived neurotrophic factor signaling at excitatory synapses without changes in AMPA receptor subunit expression. Neuroscience. 2008 Dec 24.

Lynch G, Rex CS, Chen LY, Gall CM.
The substrates of memory: defects, treatments, and enhancement. Eur J Pharmacol. 2008 May 6;585(1):2-13. Epub 2008 Mar 4. Review.

Lauterborn JC, Rex CS, Kramár E, Chen LY, Pandyarajan V, Lynch G, Gall CM.
Brain-derived neurotrophic factor rescues synaptic plasticity in a mouse model of fragile X syndrome. J Neurosci. 2007 Oct 3;27(40):10685-94.

Chen LY, Rex CS, Casale MS, Gall CM, Lynch G.
Changes in synaptic morphology accompany actin signaling during LTP. J Neurosci. 2007 May 16;27(20):5363-72.

Rex CS, Lin CY, Kramár EA, Chen LY, Gall CM, Lynch G.
Brain-derived neurotrophic factor promotes long-term potentiation-related cytoskeletal changes in adult hippocampus. J Neurosci. 2007 Mar 14;27(11):3017-29.