Working to understand: cellular mechanisms of synaptic plasticity, learning
Scientific Focus: regulation of neuronal gene expression, neurotrophic factors and adhesion molecules in neuroplasticity and neuronal survival.
Seese RR, Babayan AH, Katz AM, Cox CD, Lauterborn JC, Lynch G,
LTP induction translocates cortactin at distant synapses in wild-type but not FMR1 knock-out mice. J Neurosci. 2012 May 23;32(21):7403-13.
Kramár EA, Babayan AH, Gavin CF, Cox CD, Jafari M, Gall CM, Rumbaugh G,
Synaptic evidence for the efficacy of spaced learning. Proc Natl Acad Sci U S A. 2012 Mar 27;109(13):5121-6. Epub 2012 Mar 12.
Lynch G, Palmer LC,
The likelihood of cognitive enhancement. Pharmacol Biochem Behav. 2011 Jan 6. [Epub ahead of print]
Chen LY, Rex CS, Pham DT, Lynch G, Gall CM. BDNF signaling during learning is regionally differentiated within hippocampus. J Neurosci. 2010 Nov 10;30(45):15097-101.
Simmons DA, Mehta RA, Lauterborn JC,
Brief ampakine treatments slow the progression of Huntington's disease phenotypes in R6/2 mice. Neurobiol Dis. 2011 Feb;41(2):436-44. Epub 2010 Oct 23.
Chen, LY, CS Rex, A.H. Babayan, E.A. Kramar, G. Lynch, Journal of Neuroscience. 2010 Aug 18;30(33):10977-84.and J.C. Lauterborn. Physiological activation of synaptic Rac > PAK signaling is defective in a mouse model of Fragile-X Syndrome. In press,
Chen LY, Rex CS, Sanaiha Y, Lynch G, Proc Natl Acad Sci U S A. 2010 Apr 13;107(15):7030-5. Epub 2010 Mar 30.Learning induces neurotrophin signaling at hippocampal synapses.
Kramár EA, Chen LY, Brandon NJ, Rex CS, Liu F, Gall CM, Lynch G. Cytoskeletal changes underlie estrogen's acute effects on synaptic transmission and plasticity. J Neurosci. 2009 Oct 14;29(41):12982-93.
Rex CS, Chen LY, Sharma A, Liu J, Babayan AH, Gall CM, Lynch G. Different Rho GTPase-dependent signaling pathways initiate sequential steps in the consolidation of long-term potentiation. J Cell Biol. 2009 Jul 13;186(1):85-97.
Lynch G, Rex CS, Chen LY,
The substrates of memory: defects, treatments, and enhancement. Eur J Pharmacol. 2008 May 6;585(1):2-13. Epub 2008 Mar 4. Review.
Lauterborn JC, Rex CS, Kramár E, Chen LY, Pandyarajan V, Lynch G,
Brain-derived neurotrophic factor rescues synaptic plasticity in a mouse model of fragile X syndrome. J Neurosci. 2007 Oct 3;27(40):10685-94.
Chen LY, Rex CS, Casale MS,
Changes in synaptic morphology accompany actin signaling during LTP. J Neurosci. 2007 May 16;27(20):5363-72.
Dep't Anatomy & Neurobiology,
School of Medicine,
Gillespie Neuroscience Research Facility,
University of California,
Irvine, CA 92797-1275
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