Scientists: Alan L. Goldin, M.D., Ph.D.

Research Focus

Working to understand: Epilepsy, Myotonia, Periodic Paralysis, Cardiac Arrhythmias, Pathological Pain

Scientific Focus: Voltage-gated sodium channel mutations and CNS disease. Molecular mechanisms involved in trafficking of different CNS sodium channels.

RECENT PUBLICATIONS ON PUBMED

Selected Publications

Song W, Du Y, Liu Z, Luo N, Turkov M, Gordon D, Gurevitz M, A.L. Goldin. Dong K.
Substitutions in the domain III voltage-sensing module enhance the sensitivity of an insect sodium channel to a scorpion beta-toxin. J Biol Chem. 2011 May 6;286(18):15781-8. Epub 2011 Mar 15.

Escayg, A. and A.L. Goldin.
Sodium channel SCN1A and epilepsy: mutations and mechanisms. Epilepsia. 2010 Sep;51(9):1650-8. doi: 10.1111/j.1528-1167.2010.02640.x. Review.

Nguyen, H.M. and A.L. Goldin.
Sodium channel carboxy terminal residue regulates fast inactivation. J. Biol. Chem. Mar 19;285(12):9077-89. Epub 2010 Jan 20.

Martin, M.S., K. Dutt, L.A. Papale, C.M. Dubé, S.B. Dutton, G. de Haan, A. Shankar, S. Tufik, M.H. Meisler, T.Z. Baram, A.L. Goldin* and A. Escayg*.
Altered function of the SCN1A voltage-gated sodium channel leads to g-aminobutyric acid-ergic (GABAergic) interneuron abnormalities. J. Biol. Chem. 2010 Mar 26;285(13):9823-34. Epub 2010 Jan 25. *Co-corresponding authors.

Lee, A. and A.L. Goldin
Role of the terminal domains in sodium channel localization. Channels. 2009 May-Jun;3(3):171-80. Epub 2009 May 24.

Tang, B., K. Dutt, L. Papale, R. Rusconi, A. Shankar, J. Hunter, S. Tufik, F.H. Yu, W.A. Catterall, M. Mantegazza, A.L. Goldin* and A. Escayg*. 2009. A BAC transgenic mouse model reveals neuron subtype-specific effects of a Generalized Epilepsy with Febrile Seizures Plus (GEFS+) mutation. Neurobiol. Dis. 35:91-102. *Co-corresponding authors.

Lee A, Goldin AL
Role of the amino and carboxy termini in isoform-specific sodium channel variation. J Physiol. 2008 Aug 15;586(16):3917-26. Epub 2008 Jun 19.

Jang GM, Tanaka BS, Gutman GA, Goldin AL, Semler BL.
Alternative polyadenylation signals in the 3' non-coding region of a voltage-gated potassium channel gene are major determinants of mRNA isoform expression. Gene. 2008 Jan 31;408(1-2):133-45. Epub 2007 Nov 6

Barela, A.J., S.P. Waddy, J.G. Lickfett, J. Hunter, A. Anido, S.L. Helmers, A.L. Goldin and A. Escayg.
2006. An epilepsy mutation in the sodium channel SCN1A that decreases channel excitability. J. Neurosci. 26:2714-2723.