Working to understand: Stem cell therapies as they relate to spinal cord injury, Spinal Muscular Atrophy, multiple sclerosis and other diseases of the nervous system.
Scientific Focus: The Keirstead laboratory conducts clinically directed research that addresses both axonal regeneration and myelin regeneration following injury to the adult spinal cord.
Nazor KL, Altun G, Lynch C, Tran H, Harness JV, Slavin I, Garitaonandia I, Müller FJ, Wang YC, Boscolo FS, Fakunle E, Lee S, Park HS, Martynova M, Ole T, D’Lima D, Semechkin R, Parast MM, Galat V, Laslett AL, Schmidt U,
(2012) Recurrent Variations in DNA Methylation in Human Pluripotent Stem Cells and their Differentiated Derivatives. Cell Stem Cell. 2012 May 4;10(5):620-34. doi:10.1016/j.stem.2012.02.013
Nistor G, Siegenthaler MM, Poirier SN, Rossi S, Poole AJ, Charlton ME, McNeish JD, Airriess CN,
(2011) Derivation of high purity neuronal progenitors from human embryonic stem cells. PLoS One. 2011;6(6):e20692. Epub 2011 Jun 6.
Wyatt TJ, Rossi SL, Siegenthaler MM, Frame J, Robles R, Nistor G,
(2011) Human Motor Neuron Progenitor Transplantation Leads to Endogenous Neuronal Sparing in 3 Models of Motor Neuron Loss. Stem Cells Int. 2011;2011:207230. Epub 2011 May 23.
Laurent LC, Ulitsky I, Slavin I, Tran H, Schork A, Morey R, Lynch C, Harness JV, Lee S, Barrero MJ, Ku S, Martynova M, Semechkin R, Galat V, Gottesfeld J, Izpisua Belmonte JC, Murry C,
(2011) Dynamic Changes in the Copy Number of Pluripotency and Cell Proliferation Genes in Human ESCs and iPSCs during Reprogramming and Time in Culture. Cell Stem Cell. 2011 Jan 7;8(1):106-18.
Harness, Julie V., Turovets, Nikolay A., Seiler, Magdalene J., Nistor, Gabriel., Altun, Gulsah., Agapova, Larissa S., Ferguson, David., Laurent, Louise C., Loring, Jeanne F., and
(2011) Equivalence of Conventionally-Derived and Parthenote-Derived Human Embryonic Stem Cells. PLoS One. 2011 Jan 7;6 (1):e14499.
Laurent, L.C., Nievergelt, C.M., Lynch, C., Fakunle, E., Harness, J.V., Schmidt, U., Galat, V., Laslett, A.L., Otonkoski, T.,
(2010) Restricted ethnic diversity in human embryonic stem cell lines. Nature Methods. 7, 6-7 2010. doi:10.1038/nmeth0110-06
Rossi, Sharyn L., Nistor, Gabriel., Wyatt, Tanya., Yin, Hong Zhen., Pool, Aleksandra J., Weiss, John H., Gardner, Matthew., Dijkstra, Sipke., Fischer, David S., and
(2010) Histological and Functional Benefit Following Transplantation of Motor Neuron Progenitors to the Injured Rat Spinal Cord. PLoS One. 2010 Jul 29;5(7):e11852.
Nistor, G., Seiler, M.J., Yang, F., Ferguson, D.,
(2010) Three-dimensional early retinal progenitor 3D tissue constructs derived from human embryonic stem cells. J Neurosci Methods. 2010 Jun 30;190(1):63-70. Epub 2010 May 4.
Sharp, J., Frame, J., Siegenthaler, M., Nistor, G.,
(2010) Human Embryonic Stem Cell-Derived Oligodendrocyte Progenitor Call Transplants Improve Recovery After Cervical Spinal Cord Injury. Stem Cells. Jan;28(1):152-63.
Siegenthaler M.M., Ammon D.L.,
(2008) Myelin pathogenesis and functional deficits following SCI are age-associated. Exp Neurol. Oct;213(2):363-71. Epub 2008 Jul 3.
Sue and Bill Gross Hall; a CIRM Institute
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Magdalene Seiler, Ph.D.
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