Scientists: Hans S. Keirstead, Ph.D.

Research Focus

Working to understand: Stem cell therapies as they relate to spinal cord injury, Spinal Muscular Atrophy, multiple sclerosis and other diseases of the nervous system.

Scientific Focus: The Keirstead laboratory conducts clinically directed research that addresses both axonal regeneration and myelin regeneration following injury to the adult spinal cord.

Selected/Recent Publications

Publications Listed on PubMed

Coutts, M., Kong, L.X., Keirstead H.S.
A Model of Motor Neuron Loss: Deficits After Ricin Injection, Journal of Neurotrama. 2010. May 20.

Rooney, G., Nistor, G., Barry, F., Keirstead H.S.
In Vitro Differentiation Potential of Human Embryonic Versus Adult Stem Cells, Regenerative Medicine. 2010, May;5(3):365-79.

Seiler, M.J., Rao, B., Aramant, R.B., Yu, L., Wang, Q., Kitayama, E., Pham, S., Yan, F., Chen, Z., Keirstead, H.S.,
Three Dimensional Optical Coherence Tomography Imaging of Retinal Sheet Implants in Live Rats, J Neurosci Methods. 2010, May 15. Volume 188. Issue 2. pp. 250-257.

Seiler, M., Aramant, R.B., Thomas, B.B., Peng, Q., Sadda, S.R., Keirstead H.S.
Visual Restoration and Transplantation Connectivity in Degenerate Rats Implanted with Retinal Progenitor Sheets. Eur J Neurosci. 2010, Jan 25.

Laurent, L.C., Nievergelt, C.M., Lynch, C., Fakunle, E., Harness, J.V., Schmidt, U., Galat, V., Laslett, A.L., Otonkoski, T., Keirstead H.S., Schork, A., Park, HS. and Loring, J.F.,
Restricted ethnic diversity in human embryonic stem cell lines. Nature Methods. 7, 6-7 2010. doi:10.1038/nmeth0110-06

Sharp, J., Frame, J., Siegenthaler, M., Nistor, G., Keirstead H.S.
Human Embryonic Stem Cell-Derived Oligodendrocyte Progenitor Call Transplants Improve Recovery After Cervical Spinal Cord Injury. Stem Cells. 2010 Jan;28(1):152-63.

Sharp J., Keirstead H.S.
Stem cell-based cell replacement strategies for the central nervous system. Neurosci Lett. 2009 Jun 12;456(3):107-11. Epub 2009 Jan 16.

Hatch M.N., Nistor G., Keirstead H.S.
Derivation of high-purity oligodendroglial progenitors. Methods Mol Biol. 2009;549:59-75.

Siegenthaler M.M., Ammon D.L., Keirstead H.S.
Myelin pathogenesis and functional deficits following SCI are age-associated. Exp Neurol. 2008 Oct;213(2):363-71. Epub 2008 Jul 3.

Siegenthaler M.M., Berchtold N.C., Cotman C.W., Keirstead H.S
Voluntary running attenuates age-related deficits following SCI. Exp Neurol. 2008 Mar;210(1):207-16. Epub 2007 Nov 13.

Siegenthaler M.M., Tu M.K., Keirstead H.S.
The extent of myelin pathology differs following contusion and transection spinal cord injury. J Neurotrauma. 2007 Oct;24(10):1631-46.

Coutts M., Keirstead H.S.
Stem cells for the treatment of spinal cord injury.
Exp Neurol. 2008 Feb;209(2):368-77. Epub 2007 Sep 12. Review.

Gonzalez R., Hickey M.J., Espinosa J.M., Nistor G., Lane T.E., Keirstead H.S.
Therapeutic neutralization of CXCL10 decreases secondary degeneration and functional deficit after spinal cord injury in mice. Regen Med. 2007 Sep;2(5):771-83.

Radojicic M., Nistor G., Keirstead H.S.
Ascending central canal dilation and progressive ependymal disruption in a contusion model of rodent chronic spinal cord injury.
BMC Neurol. 2007 Sep 7;7:30.

Cloutier F., Siegenthaler M.M., Nistor G., Keirstead H.S.
Transplantation of human embryonic stem cell-derived oligodendrocyte progenitors into rat spinal cord injuries does not cause harm. Regen Med. 2006 Jul;1(4):469-79.

Nayak M.S., Kim Y.S., Goldman M., Keirstead H.S., Kerr D.A.,
Cellular therapies in motor neuron diseases. Biochem Biophys Acta. 2006 Nov-Dec;1762(11-12):1128-38. Epub 2006 Jun 17. Review.