Working to understand: underlying causes of mental retardation in fragile X, autism, and related disorders, understanding the mechanisms of learning and memory, how they are disturbed in these syndromes and how stress contributes to the cognitive and behavioral disturbances in these disorders. These studies have lead to potential therapeutics strategies which we continue to investigate.
Scientific Focus: Regulation of neurotrophic factor expression Fragile X, developmental disorders, and mental retardation
Jafari M, Seese RR, Babayan AH, Gall CM,
Glucocorticoid Receptors are Localized to Dendritic Spines and Influence Local Actin Signaling. Mol Neurobiol. 2012 Jun 21. [Epub ahead of print]
Seese RR, Babayan AH, Katz AM, Cox CD,
LTP induction translocates cortactin at distant synapses in wild-type but not FMR1 knock-out mice. J Neurosci. 2012 May 23;32(21):7403-13.
Simmons DA, Mehta RA,
Brief ampakine treatments slow the progression of Huntington's disease phenotypes in R6/2 mice. Neurobiol Dis. 2011 Feb;41(2):436-44. Epub 2010 Oct 23.
Chen LY, Rex CS, Babayan AH, Kramár EA, Lynch G, Gall CM,
Physiological activation of synaptic Rac>PAK (p-21 activated kinase) signaling is defective in a mouse model of fragile X syndrome. J Neurosci. 2010 Aug 18;30(33):10977-84.
Kramár EA, Chen LY,
BDNF upregulation rescues synaptic plasticity in middle-aged ovariectomized rats. Neurobiol Aging. 2010 Jul 29. [Epub ahead of print]
, Pineda E, Chen LY, Ramirez EA, Lynch G, Gall CM.
Ampakines cause sustained increases in brain-derived neurotrophic factor signaling at excitatory synapses without changes in AMPA receptor subunit expression. Neuroscience. 2009 Mar 3;159(1):283-95. Epub 2008 Dec 24.
, Rex CS, Kramár E, Chen LY, Pandyarajan V, Lynch G, Gall CM.
Brain-derived neurotrophic factor rescues synaptic plasticity in a mouse model of fragile X syndrome. J Neurosci. 2007 Oct 3;27(40):10685-94.
3119 Gillespie Neuroscience Research Facility,
University of California, Irvine, CA 92697-4292
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