Emeritus Faculty

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Scientist: Gary Lynch, Ph.D

Dr. Gary Lynch


Psychiatry & Human Behavior
Anatomy & Neurobiology

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Research Description

Working to understand: disorders of learning and memory

Scientific Focus: synaptic plasticity, LTP


Selected Publications

*Seese R.R., *Chen L.Y., Schultz D., W. Bunney, F. Henn, C.M. Gall, Lynch G,
(2013) Reduced Numbers of Cortical Glutamatergic Synapses in a Rat Model of Chronic Depression. J. Neurosci. 33: 13441-13448.  *Contributed equally to the work.

Trieu B.H., E.A. Kramar, W. Wang, C.D. Cox, C.M. Gall, and Lynch G,
2015 Differences in adenosine processing create marked regional variations in post-induction shaping of memory related synaptic changes. J. Physiology, 593 (13): 2889-2907. doi: 10.1113/JP270398

Lynch G, Kramar EA, Gall CM.
2015. Protein synthesis and consolidation of memory-related synaptic changes. Brain Res 1621:62-72.

Cox C.D., Rex C.S., Palmer L.C., Babayan A.H., Pham D.T., Corwin S.D., Trieu B.H., Gall C.M., Lynch G,
(2014). A map of LTP-related synaptic changes in dorsal hippocampus following unsupervised learning. J Neurosci 34, 3033-3041.

Lynch G, Cox C.D., and Gall C.M.
2014 Pharmacological enhancement of memory or cognition in normal subjects. Front Syst Neurosci.8:90. doi: 10.3389/fnsys.2014.00090. eCollection 2014.  PMCID: PMC4033242

Seese, R.R., Y.Q. Yao, K. Wang, Lynch G, and C.M. Gall
2014 Spaced training rescues memory and synaptic ERK1/2 signaling in a mouse model of fragile X syndrome. Proc Natl Acad Sci, USA. Nov 25;111(47):16907-12. doi: 10.1073/pnas.1413335111.

Ozkan ED, Creson TK, Kramar EA, Rojas C, Seese RR, Babyan AH, Shi Y, Lucero R, Xu X, Noebels JL, Miller CA, Lynch G, & Rumbaugh G (2014).
Reduced cognition in Syngap1 mutants is caused by isolated damage within developing forebrain excitatory neurons. Neuron 82, 1317-1333.

Kramár EA, Babayan AH, Gavin CF, Cox CD, Jafari M, Gall CM, Rumbaugh G, Lynch G.
Synaptic evidence for the efficacy of spaced learning. Proc Natl Acad Sci U S A. 2012 Mar 27;109(13):5121-6. Epub 2012 Mar 12.

Baudry M, Kramar E, Xu X, Zadran H, Moreno S, Lynch G, Gall C, Bi X.
Ampakines promote spine actin polymerization, long-term potentiation, and learning in a mouse model of Angelman syndrome. Neurobiol Dis. 2012 Aug;47(2):210-5. Epub 2012 Apr 16.

Seese RR, Babayan AH, Katz AM, Cox CD, Lauterborn JC, Lynch G, Gall CM.
LTP induction translocates cortactin at distant synapses in wild-type but not FMR1 knock-out mice. J Neurosci. 2012 May 23;32(21):7403-13.

Simmons, D.A., R. Metha, J.C. Lauterborn, C.M. Gall and G. Lynch (2011)
Brief ampakine treatments slow the progression of Huntington’s Disease phenotypes in mice. Neurobiol. Disease, 41:436-444.

Barrett RM, Malvaez M, Kramar E, Matheos DP, Arrizon A, Cabrera SM, Lynch G, Greene RW, Wood MA.
Hippocampal focal knockout of CBP affects specific histone modifications, long-term potentiation, and long-term memory. Neuropsychopharmacology. 2011 Jul;36(8):1545-56. doi: 10.1038/npp.2011.61. Epub 2011 Apr 20.

Clarkson AN, Overman JJ, Zhong S, Mueller R, Lynch G, Carmichael ST.
AMPA receptor-induced local brain-derived neurotrophic factor signaling mediates motor recovery after stroke. J Neurosci. 2011 Mar 9;31(10):3766-75.

Lynch G, Palmer LC, Gall CM.
The likelihood of cognitive enhancement. Pharmacol Biochem Behav. 2011 Aug;99(2):116-29. Epub 2011 Jan 6. Review.

Chen LY, Rex CS, Pham DT, Lynch G, Gall CM.
BDNF signaling during learning is regionally differentiated within hippocampus. J Neurosci. 2010 Nov 10;30(45):15097-101.

Jia Y, Gall CM, Lynch G.
Presynaptic BDNF promotes postsynaptic long-term potentiation in the dorsal striatum.
J Neurosci. 2010 Oct 27;30(43):14440-5.

Rex CS, Gavin CF, Rubio MD, Kramar EA, Chen LY, Jia Y, Huganir RL, Muzyczka N, Gall CM, Miller CA, Lynch G, Rumbaugh G.
Myosin IIb regulates actin dynamics during synaptic plasticity and memory formation.
Neuron. 2010 Aug 26;67(4):603-17.

Contact Information








Psychiatry & Human Behavior
101 Theory, Suite 250
University of California
Irvine, California 92697-4292

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