Working to understand: neuronal plasticity underlying learning and memory, cellular mechanisms contributing to generation of febrile seizures (GEFS+, SMEI), and how to improve science education in research universities.
Scientific Focus: regulation of excitability and synaptic transmission in the central nervous system in flies, mice, and induced pluripotent stem cell (iPSC) derived neurons from patients with inherited neurological disorders (GEFS+, SMEI), effect of different teaching strategies on learning outcomes in large introductory biology classes.
Stover, A., D. Brick, H. Nethercott, M. Banuelos, L. Sun,
(2013) Process-based expansion and Neural differentation of human pluripotent stem cells for transplantation and disease-modeling. J. Neuroscience Research, in press.
Sun, L., J. Gilligan, C. Staber, R.J. Schutte, V. Nguyen,
(2012) A knock-in model of human epilepsy in Drosophila reveals a novel cellular mechanism associated with heat-induced seizure. J. Neurosci. 32: 14145-14155. *co-corresponding authors
Aguilar-Roca, N.M., A. E. Williams, and
(2012) The impact of laptop-free zones on student performance and attitudes in large lectures. Computers & Education 59: 1300-1308.
William AE, Aguilar-Roca NM, Tsai M, Wong M, Beaupre MM,
(2011) Assessment of learning gains associated with independent exam analysis in introductory biology. CBE Life Sci Educ. Winter;10(4):346-56. doi: 10.1187/cbe.11-03-0025.
Ren P, Zhang H, Qiu F, Liu YQ, Gu H,
(2011) CBE Life Sci Educ. 2011 Winter;10(4):346-56. doi: 10.1187/cbe.11-03-0025. Prokineticin 2 regulates the electrical activity of rat suprachiasmatic nuclei neurons. PLoS One. ;6(6):e20263. Epub 2011 Jun 8.
Anderson WA, Banerjee U, Drennan CL, Elgin SC, Epstein IR, Handelsman J, Hatfull GF, Losick R,
( 2011) Science education. Changing the culture of science education at research universities. Science. Jan 14;331(6014):152-3. No abstract available.
Moravec M, Williams A, Aguilar-Roca N,
(2010) Learn before lecture: A strategy that improves learning outcomes in a large introductory biology class. CBE Life Sci Educ. Winter;9(4):473-81.
Gu*, H., S.A. Jiang*, J.M. Campusano*, J. Iniguez*, H. Su, A.A. Hoang, M. Lavian, X. Sun, and
(2009) Cav2-type calcium channels encoded by cac regulate AP-independent neurotransmitter release at cholinergic synapses in adult Drosophila brain. J. Neurophysiol. 101: 42-53. * authors contributed equally.
(2009) Garage Demos: Using physical models to illustrate dynamic aspects of microscopic processes. Cell Biology Education 8: 118-122.
Oh, H-W, J,M. Campusano, L.G.W. Hilgenberg, X. Sun, M.A. Smith, and Dev. Neurobiology 68: 281-294.(2008) Ultrastructural analysis of chemical synapses and gap junctions between Drosophila brain neurons in culture.
Dep't Anatomy & Neurobiology,
School of Medicine,
112 Irvine Hall,
University of California, Irvine, CA 92697-1280
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