Emeritus Faculty

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Scientist: Charles E. Ribak, Ph.D

Dr. Charles E. Ribak

Professor Emeritus:

Anatomy & Neurobiology

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Research Focus

Working to understand: temporal lobe epilepsy

Scientific Focus: My laboratory used a rat model of temporal lobe epilepsy that involves injecting a chemoconvulsant, pilocarpine. The main region of the brain affected in this type of epilepsy is the hippocampus. I have contributed in recent years by showing newly generated neurons in the dentate gyrus of the adult hippocampus form basal dendrites that are involved in recurrent excitatory circuitry. This type of circuitry may be the basis for seizure activity in these rats. Recently, I have examined the role of neuroglia in epilepsy and discovered a new type of neuronal death involving microglia. This form of neuronal death occurs in brain regions where adult neurogenesis is found and thus may be involved in the homeostasis of the number of neurons in these brain regions.

Publications Listed on PubMed

Selected/Recent Publications

Seizure-induced formation of basal dendrites on granule cells of the rodent dentate gyrus.
Ribak CE , Shapiro LA, Yan XX, Dashtipour K, Nadler JV, Obenaus A, Spigelman I, Buckmaster PS. In: Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV, editors.
Jasper's Basic Mechanisms of the Epilepsies [Internet]. 4th edition. Bethesda (MD): National Center for Biotechnology Information (US); 2012.

Synaptic connections of hilar basal dendrites of dentate granule cells in a neonatal hypoxia model of epilepsy.
Sanchez RM, Ribak CE, Shapiro LA.
Epilepsia. 2012 Jun;53 Suppl 1:98-108.

Astrocyte Alterations in the Hippocampus Following Pilocarpine-induced Seizures in Aged Rats.
Arisi GM, Ruch M, Foresti ML, Mukherjee S, Ribak CE, Shapiro LA.
Aging Dis. 2011 Aug;2(4):294-300. Epub 2011 Aug 30.

Seizure-induced Increased Neurogenesis Occurs in the Dentate Gyrus of Aged Sprague-Dawley Rats.
Shapiro LA, Wang L, Upadhyaya P, Ribak CE.
Aging Dis. 2011 Aug;2(4):286-93. Epub 2011 Aug 30.

Microglia-associated granule cell death in the normal adult dentate gyrus.
Ribak CE, Shapiro LA, Perez ZD, Spigelman I.
Brain Struct Funct. 2009 Dec;214(1):25-35.

Morphological and ultrastructural features of Iba1-immunolabeled microglial cells in the hippocampal dentate gyrus.
Shapiro, L.A., Perez, Z.D., Foresti, M.L., Arisi, G.M. and Ribak, C.E.
Brain Res. 1266: 29-36 (2009). Cover Photo-micrograph.

Dentate granule cells form hilar basal dendrites in a rat model of hypoxia-ischemia. Díaz-Cintra, S., Xue, B., Spigelman, I., Van, K., Wong, A.M., Obenaus, A. and Ribak, C.E.,
Brain Res. 1285: 182-187 (2009).

Proximity of excitatory and inhibitory axon terminals adjacent to pyramidal cell bodies provides a putative basis for nonsynaptic interactions. Merchán-Pérez, A., Rodriguez, J.R., Ribak, C.E. and DeFelipe, J.
Proc. Natl. Acad. Sci. USA, 106: 9878-9883 (2009).

Long-term survival of olfactory sensory neurons after target depletion.
Sultan-Styne, K., Toledo, R., Walker, C., Kallkopf, A., Ribak, C.E. and Guthrie, K.M.
J. Comp. Neurol. 515: 696-710 (2009).

Subventricular zone-derived, newly generated neurons populate several olfactory and limbic forebrain regions.
Shapiro LA, Ng K, Zhou QY, Ribak CE.
Epilepsy Behav. 2009 Jan;14 Suppl 1:74-80. Epub 2008 Oct 26.

Structural changes for adult-born dentate granule cells after status epilepticus.
Shapiro LA, Ribak CE, Jessberger S.
Epilepsia. 2008 Jun;49 Suppl 5:13-8. Review.

Neurons born in the adult dentate gyrus form functional synapses with target cells.
Toni N, Laplagne DA, Zhao C, Lombardi G, Ribak CE, Gage FH, Schinder AF.
Nat Neurosci. 2008 Aug;11(8):901-7. Epub 2008 Jul 11.

Synaptic input to dentate granule cell basal dendrites in a rat model of temporal lobe epilepsy.
Thind KK, Ribak CE, Buckmaster PS.
J Comp Neurol. 2008 Jul 10;509(2):190-202.

In DRG11 knock-out mice, trigeminal cell death is extensive and does not account for failed brainstem patterning. </
Jacquin MF, Arends JJ, Xiang C, Shapiro LA, Ribak CE, Chen ZF.

J Neurosci. 2008 Apr 2;28(14):3577-85.

Rapid astrocyte and microglial activation following pilocarpine-induced seizures in rats.
Shapiro LA, Wang L, Ribak CE.
Epilepsia. 2008;49 Suppl 2:33-41.

Contact Information








Dep't Anatomy & Neurobiology,
School of Medicine,
University of California,
Irvine, CA 92697-1280

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