Anatomy & Neurobiology
School of Biological Sciences
Chao Comprehensive Cancer Center
Working to Understand:
cell surface molecules that identify certain classes of cells.
Scientific Foci, Cancer: use of peptide-containing liposomes and immuno-liposomes to identify cell surface molecules of tumor cells for delivery of chemotherapeutic drugs specifically to targeted cancer cells.
Scientific Foci, Neuroscience: studies of expression of cell-secreted neurotrophins that aid axonal target selection in developing cerebral cortex, including both neocortex and hippocampal formation. Experiments use tissue slice and dissociated cell culture techniques to understand how expression of neurotrophin-3 guides cholinergic axons to form synapses with cortical neurons.
List 1: Cancer Drug Delivery
List 2: Neuroscience
Development, differentiation, and vascular components of subcutaneous and intrahepatic Hepa129 tumors in a mouse model of hepatocellular carcinoma.
Gutierrez P. M., Baratta, J.L., Thordarson, K., Braslow, J., Haynes, S.M. and Longmuir, K.J., Histology and Histopathology 2016; 31: 403-413
Use of labeled tomato lectin for imaging vasculature structures.
Levine ST, Haynes SM, Gutierrez P, Baratta JL, Tan Z, Longmuir KJ., Histochem Cell Biol. 2015 Feb;143(2):225-34. doi: 10.1007/s00418-014-1301-3. Epub 2014 Dec 23.
Binding patterns of peptide-containing liposomes in liver and spleen of developing mice: comparison with heparan sulfate immunoreactivity.
Tsai MS, Baratta JL, Longmuir KJ,
J Drug Target. 2011 Aug;19(7):506-15. Epub 2010 Aug 24.
Cellular organization of normal mouse liver: a histological, quantitative immunocytochemical, and fine structural analysis.
Baratta JL, Ngo A, Lopez B, Kasabwalla N, Longmuir KJ,
Histochem Cell Biol. 2009 Jun;131(6)Ω:713-26. Epub 2009 Mar 3.
Effective targeting of liposomes to liver and hepatocytes in vivo by incorporation of a Plasmodium amino acid sequence.
Longmuir KJ, , Haynes SM, Baratta JL, Waring AJ.
Pharm Res. 2006 Apr;23(4):759-69. Epub 2006 Mar 24.
Amyloid-beta expression in retrosplenial cortex of triple transgenic mice: relationship to cholinergic axonal afferents from medial septum.
, Baratta J, Yu J, LaFerla FM.
Neuroscience. 2009 Dec 15;164(3):1334-46. Epub 2009 Sep 20.
Re-growth of catecholaminergic fibers and protection of cholinergic spinal cord neurons in spinal repaired rats.
Lee YS, Lin CY, , Yu J, Deng X, Hsiao I, Lin VW. Eur J Neurosci. 2006 Feb;23(3):693-702.
Dep't Anatomy & Neurobiology, School of Medicine,
University of California,
Irvine, CA 92697-1280
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