Scientists: Richard T. Robertson, Ph.D.

Research

Working to Understand: cell surface molecules that identify certain classes of cells.

       Scientific Foci, Cancer: use of peptide-containing liposomes and immuno-liposomes to identify cell surface molecules of tumor cells for delivery of chemotherapeutic drugs specifically to targeted cancer cells.

       Scientific Foci, Neuroscience: studies of expression of cell-secreted neurotrophins that aid axonal target selection in developing cerebral cortex, including both neocortex and hippocampal formation. Experiments use tissue slice and dissociated cell culture techniques to understand how expression of neurotrophin-3 guides cholinergic axons to form synapses with cortical neurons.

RECENT PUBLICATIONS ON PUBMED

Selected Publications

   List 1: Cancer Drug Delivery
   List 2: Neuroscience

1: Cancer Drug Delivery

Lopez BG, Tsai MS, Baratta JL, Longmuir KJ, Robertson RT.
Characterization of Kupffer cells in livers of developing mice. Comp Hepatol. 2011 Jul 12;10(1):2.

Tsai MS, Baratta JL, Longmuir KJ, Robertson RT.
Binding patterns of peptide-containing liposomes in liver and spleen of developing mice: comparison with heparan sulfate immunoreactivity. J Drug Target. 2011 Aug;19(7):506-15. Epub 2010 Aug 24.

Tsai MS, Baratta JL, Longmuir KJ, Robertson RT.
Binding patterns of peptide-containing liposomes in liver and spleen of developing mice: comparison with heparan sulfate immunoreactivity. J Drug Target. 2010 Aug 24. [Epub ahead of print]

Longmuir KJ, Haynes SM, Baratta JL, Kasabwalla N, Robertson RT.
Liposomal delivery of doxorubicin to hepatocytes in vivo by targeting heparan sulfate. Int J Pharm.. 2009 Dec 1;382(1-2):222-33. Epub 2009 Aug 5.

Baratta JL, Ngo A, Lopez B, Kasabwalla N, Longmuir KJ, Robertson RT.
Cellular organization of normal mouse liver: a histological, quantitative immunocytochemical, and fine structural analysis. Histochem Cell Biol. 2009 Jun;131(6)Ω:713-26. Epub 2009 Mar 3.

Robertson RT, Baratta JL, Haynes SM, Longmuir KJ.
Liposomes incorporating a Plasmodium amino acid sequence target heparan sulfate binding sites in liver. J Pharm Sci. 2008 Aug;97(8):3257-73.

Longmuir KJ, Robertson RT, Haynes SM, Baratta JL, Waring AJ.
Effective targeting of liposomes to liver and hepatocytes in vivo by incorporation of a Plasmodium amino acid sequence. Pharm Res. 2006 Apr;23(4):759-69. Epub 2006 Mar 24.

1: Neuroscience

Robertson RT, Baratta J, Yu J, LaFerla FM.
Amyloid-beta expression in retrosplenial cortex of triple transgenic mice: relationship to cholinergic axonal afferents from medial septum. Neuroscience. 2009 Dec 15;164(3):1334-46. Epub 2009 Sep 20.

Robertson RT, Baratta J, Yu J, Guthrie KM.
A role for neurotrophin-3 in targeting developing cholinergic axon projections to cerebral cortex. Neuroscience. 2006 Dec 1;143(2):523-39. Epub 2006 Oct 13.

Lee YS, Lin CY, Robertson RT, Yu J, Deng X, Hsiao I, Lin VW.
Re-growth of catecholaminergic fibers and protection of cholinergic spinal cord neurons in spinal repaired rats. Eur J Neurosci. 2006 Feb;23(3):693-702.

Guthrie KM, Tran A, Baratta J, Yu J, Robertson RT.
Patterns of afferent projections to the dentate gyrus studied in organotypic co-cultures. Brain Res Dev Brain Res. 2005 Jun 30;157(2):162-71.