Emeritus Faculty

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Scientist: Oswald Steward, Ph.D

Dr. Oswald Steward

Senior Associate Dean for Research:


Anatomy & Neurobiology
Neurobiology & Behavior


Reeve-Irvine Research Center

Research Focus

Working to understand: spinal cord injury, neurodegenerative disorders, learning and memory, epilepsy, mental retardation syndromes

Scientific Focus: recovery of function following damage to the nervous system. mRNA trafficking.


Selected Publications

Chao T, Frump D, Lin M, Caiozzo VJ, Mozaffar T, Steward O, Gupta R.
Matrix metalloproteinase 3 deletion preserves denervated motor endplates after traumatic nerve injury. Ann Neurol. 2013 Feb;73(2):210-23.

Landis SC, Amara SG, Asadullah K, Austin CP, Blumenstein R, Bradley EW, Crystal RG, Darnell RB, Ferrante RJ, Fillit H, Finkelstein R, Fisher M, Gendelman HE, Golub RM, Goudreau JL, Gross RA, Gubitz AK, Hesterlee SE, Howells DW, Huguenard J, Kelner K, Koroshetz W, Krainc D, Lazic SE, Levine MS, Macleod MR, McCall JM, Moxley RT 3rd, Narasimhan K, Noble LJ, Perrin S, Porter JD, Steward O, Unger E, Utz U, Silberberg SD.
A call for transparent reporting to optimize the predictive value of preclinical research. Nature. 2012 Oct 11;490(7419):187-91.

Tuszynski MH, Steward O.
Concepts and methods for the study of axonal regeneration in the CNS. Neuron. 2012 Jun 7;74(5):777-91.

Dynes JL, Steward O.
Arc mRNA docks precisely at the base of individual dendritic spines indicating the existence of a specialized microdomain for synapse-specific mRNA translation. J Comp Neurol. 2012 Feb 20. doi: 10.1002/cne.23073. [Epub ahead of print]

Steward O, Popovich PG, Dietrich WD, Kleitman N.
Replication and reproducibility in spinal cord injury research. Exp Neurol. 2012 Feb;233(2):597-605. Epub 2011 Nov 10.

Nielson JL, Sears-Kraxberger I, Strong MK, Wong JK, Willenberg R, Steward O.
Unexpected survival of neurons of origin of the pyramidal tract after spinal cord injury. J Neurosci. 2010 Aug 25;30(34):11516-28.

Liu K, Lu Y, Lee JK, Samara R, Willenberg R, Sears-Kraxberger I, Tedeschi A, Park KK, Jin D, Cai B, Xu B, Connolly L, Steward O, Zheng B, He Z.
PTEN deletion enhances the regenerative ability of adult corticospinal neurons. Nat Neurosci. 2010 Sep;13(9):1075-81. Epub 2010 Aug 8.

Chotiner JK, Nielson J, Farris S, Lewandowski G, Huang F, Banos K, de Leon R, Steward O.
Assessment of the role of MAP kinase in mediating activity-dependent transcriptional activation of the immediate early gene Arc/Arg3.1 in the dentate gyrus in vivo. Learn Mem. 2010 Feb 13;17(2):117-29. Print 2010.

Steward O, Zheng B, Tessier-Lavigne M, Hofstadter M, Sharp K, Yee KM.
Regenerative growth of corticospinal tract axons via the ventral column after spinal cord injury in mice. J Neurosci. 2008 Jul 2;28(27):6836-47.

Steward O, Sharp K, Yee KM, Hofstadter M.
A re-assessment of the effects of a Nogo-66 receptor antagonist on regenerative growth of axons and locomotor recovery after spinal cord injury in mice. Exp Neurol. 2008 Feb;209(2):446-68. Epub 2007 Dec 23.

Huang F, Chotiner JK, Steward O.
Actin polymerization and ERK phosphorylation are required for Arc/Arg3.1 mRNA targeting to activated synaptic sites on dendrites. J Neurosci. 2007 Aug 22;27(34):9054-67.

Contact Information








Dep't Anatomy & Neurobiology,
Gillespie Neuroscience Research Facility,
University of California, Irvine, CA 92697-4265

The Lab

Gail Lewandowski
Project Scientist
Camelia Danilov
Postdoctoral Fellow
Joseph Bonner
Postdoctoral Fellow
Zachary Gallagher
Postdoctoral Fellow
Rafer Willenberg
Graduate Student
Patricia Salgado
Graduate Student
Rafer Willenberg
Graduate Student
Erin Gutilla
Graduate Student

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