Scientists: Oswald Steward, Ph.D.

Research Focus

Working to understand: spinal cord injury, neurodegenerative disorders, learning and memory, epilepsy, mental retardation syndromes

Scientific Focus: recovery of function following damage to the nervous system. mRNA trafficking.

Selected/Recent Publications

Publications Listed on PubMed

Chotiner JK, Nielson J, Farris S, Lewandowski G, Huang F, Banos K, de Leon R, Steward O.
Assessment of the role of MAP kinase in mediating activity-dependent transcriptional activation of the immediate early gene Arc/Arg3.1 in the dentate gyrus in vivo. Learn Mem. 2010 Feb 13;17(2):117-29. Print 2010.

Miyashita T, Kubik S, Haghighi N, Steward O, Guzowski JF.
Rapid activation of plasticity-associated gene transcription in hippocampal neurons provides a mechanism for encoding of one-trial experience. J Neurosci. 2009 Jan 28;29(4):898-906.

Liu Y, Wang X, Lu CC, Kerman R, Steward O, Xu XM, Zou Y.
Repulsive Wnt signaling inhibits axon regeneration after CNS injury.
J Neurosci. 2008 Aug 13;28(33):8376-82.

Steward O, Zheng B, Tessier-Lavigne M, Hofstadter M, Sharp K, Yee KM.
Regenerative growth of corticospinal tract axons via the ventral column after spinal cord injury in mice. J Neurosci. 2008 Jul 2;28(27):6836-47.

Steward O, Sharp K, Yee KM, Hofstadter M.
A re-assessment of the effects of a Nogo-66 receptor antagonist on regenerative growth of axons and locomotor recovery after spinal cord injury in mice. Exp Neurol. 2008 Feb;209(2):446-68. Epub 2007 Dec 23.

Chao T, Pham K, Steward O, Gupta R.
Chronic nerve compression injury induces a phenotypic switch of neurons within the dorsal root ganglia. J Comp Neurol. 2008 Jan 10;506(2):180-93.

McLin JP, Thompson LM, Lusis AJ, Davis RC, Steward O.
Genes on distal chromosome 18 determine vulnerability to excitotoxic neurodegeneration following status epilepticus, but not striatal neurodegeneration induced by quinolinic acid. Neurobiol Dis. 2008 Mar;29(3):391-9. Epub 2007 Oct 11.

Huang F, Chotiner JK, Steward O.
Actin polymerization and ERK phosphorylation are required for Arc/Arg3.1 mRNA targeting to activated synaptic sites on dendrites. J Neurosci. 2007 Aug 22;27(34):9054-67.