Emeritus Faculty

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Scientists:  Xiangmin Xu, Ph.D

Dr. Xiangmin Xu

Associate Professor:

Anatomy & Neurobiology

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Research Focus

Working to understand: underlying mechanisms related to learning and memory disorders, epilepsy, and schizophrenia.

Scientific Focus: cell-type specific cortical circuit organization and function (electrophysiology, optical stimulation, imaging, molecular genetics, viral tracing).


Selected Publications

Sun, Y., Nguyen, A., Nguyen, J., Le, L., Saur, D., Choi, J., Callaway, E.M., Xu, X. (2014) Cell-type specific circuit connectivity of hippocampal CA1 revealed through Cre-dependent rabies tracing. Cell Reports 7: 269–280. http://dx.doi.org/10.1016/j.celrep.2014.02.030.

Parks, G. #, Olivas, N.D. #, Ikrar, T. #, Sanathara, N., Wang, L., Wang, Z., Civelli, O. *, Xu, X. * (2014) Histamine inhibits the melanin-concentrating hormone system: Implications for sleep and arousal. Journal of Physiology (http://jp.physoc.org/content/early/2014/03/17/jphysiol.2013.268771.long) [Epub ahead of print] [PMID: 24639485]   # Co-first authors; * Co-corresponding authors

Shi, Y.,  Ikrar, T.,  Olivas, N.D., Xu, X. (2013) Bi-directional global spontaneous network activity immediately precedes the canonical unidirectional circuit organization in the developing hippocampus. Journal of Comparative Neurology (2013 doi: 10.1002/cne.23528). [Epub ahead of print]  

Andrew, S., Liban, K., Ikrar, T., Tsyganovskiy, E., Xu, X. (2013). Distinct physiological and developmental properties of hippocampal CA2 subfield revealed using anti-Purkinje cell protein 4 (PCP4) immunostaining.  Journal of Comparative Neurology (2013 doi: 10.1002/cne.23486). [Epub ahead of print] 

Ikrar, T., Guo, N., He, K., Besnard, A., Levinson, S., Hill, A., Lee, H., Hen, R., Xu, X.*, Sahay, A.* (2013) Adult neurogenesis modifies excitability of the dentate gyrus. Frontiers in Neural Circuits (2013 doi: 10.3389/fncir.2013.00204).  * Co-corresponding authors 

Kuhlman, S.J. #, Olivas, N.D. #, Tring, E., Ikrar, T., Xu, X.*, Trachtenberg, J.T.*
(2013) A disinhibitory microcircuit initiates critical period plasticity in visual cortex. Nature (Advanced Online Publication): August 2013. DOI: 10.1038/nature12485.
#Co-first authors; * Co-corresponding Authors.

Haettig J, Sun Y, Wood MA, Xu X.
Cell-type specific inactivation of hippocampal CA1 disrupts location-dependent object recognition in the mouse. Learn Mem. 2013 Feb 15;20(3):139-46.

Ahrar S, Nguyen TV, Shi Y, Ikrar T, Xu X, Hui EE.
Optical stimulation and imaging of functional brain circuitry in a segmented laminar flow chamber. Lab Chip. 2013 Feb 21;13(4):536-41.

Clement JP, Aceti M, Creson TK, Ozkan ED, Shi Y, Reish NJ, Almonte AG, Miller BH, Wiltgen BJ, Miller CA, Xu X, Rumbaugh G.
Pathogenic SYNGAP1 mutations impair cognitive development by disrupting maturation of dendritic spine synapses. Cell. 2012 Nov 9;151(4):709-23.Select item 23060751

Olivas ND, Quintanar-Zilinskas V, Nenadic Z, Xu X.
Laminar circuit organization and response modulation in mouse visual cortex. Front Neural Circuits. 2012;6:70.

Shi Y, Nenadic Z, Xu X.
Novel use of matched filtering for synaptic event detection and extraction. PLoS One. 2010 Nov 24;5(11):e15517.

Xu, X., Olivas, N.D., Levi, R., Ikrar, T., Nenadic, Z.
High precision and fast functional mapping of cortical circuitry through a novel combination of voltage sensitive dye imaging and laser scanning photostimulation. Journal of Neurophysiolog. 2010 Apr;103(4):2301-12.

Contact Information








Dep't Anatomy & Neurobiology,
362 Med Surge II,
School of Medicine,
University of California,
Irvine CA 92697-1275

The Lab

Taruna Ikrar
Assistant Specialist
Yulin Shi
Assistant Specialist
Yanjun Sun
Graduate Student

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