Working to understand: underlying mechanisms related to learning and memory disorders, epilepsy, and schizophrenia.
Scientific Focus: cell-type specific cortical circuit organization and function (electrophysiology, optical stimulation, imaging, molecular genetics, viral tracing).
Kuhlman, S.J. #, Olivas, N.D. #, Tring, E., Ikrar, T.,
(2013) A disinhibitory microcircuit initiates critical period plasticity in visual cortex. Nature (Advanced Online Publication): August 2013. DOI: 10.1038/nature12485.
#Co-first authors; * Co-corresponding Authors.
Haettig J, Sun Y, Wood MA,
Cell-type specific inactivation of hippocampal CA1 disrupts location-dependent object recognition in the mouse. Learn Mem. 2013 Feb 15;20(3):139-46.
Ahrar S, Nguyen TV, Shi Y, Ikrar T,
Optical stimulation and imaging of functional brain circuitry in a segmented laminar flow chamber. Lab Chip. 2013 Feb 21;13(4):536-41.
Clement JP, Aceti M, Creson TK, Ozkan ED, Shi Y, Reish NJ, Almonte AG, Miller BH, Wiltgen BJ, Miller CA,
Pathogenic SYNGAP1 mutations impair cognitive development by disrupting maturation of dendritic spine synapses. Cell. 2012 Nov 9;151(4):709-23.Select item 23060751
Olivas ND, Quintanar-Zilinskas V, Nenadic Z,
Laminar circuit organization and response modulation in mouse visual cortex. Front Neural Circuits. 2012;6:70.
Ikrar T, Shi Y, Velasquez T, Goulding M,
Cell-type specific regulation of cortical excitability through the allatostatin receptor system. Front Neural Circuits. 2012;6:2. Epub 2012 Jan 20.
Shi Y, Nenadic Z,
Novel use of matched filtering for synaptic event detection and extraction. PLoS One. 2010 Nov 24;5(11):e15517.
High precision and fast functional mapping of cortical circuitry through a novel combination of voltage sensitive dye imaging and laser scanning photostimulation. Journal of Neurophysiolog. 2010 Apr;103(4):2301-12.
Laminar specificity of functional input to distinct types of inhibitory cortical neurons. Journal of Neuroscience. 2009 Jan 7;29(1):70-85.
Dep't Anatomy & Neurobiology,
362 Med Surge II,
School of Medicine,
University of California,
Irvine CA 92697-1275
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